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Alternatives For Dermal Toxicity Testing

Alternatives for Dermal Toxicity Testing PDF
Author: Chantra Eskes
Publisher: Springer
Release: 2017-11-21
ISBN: 3319503537
Size: 25.67 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 592
View: 6840

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Alternatives For Dermal Toxicity Testing

by Chantra Eskes, Alternatives For Dermal Toxicity Testing Books available in PDF, EPUB, Mobi Format. Download Alternatives For Dermal Toxicity Testing books, This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.



Alternative Toxicological Methods

Alternative Toxicological Methods PDF
Author: Harry Salem
Publisher: CRC Press
Release: 2003-03-26
ISBN: 9780203008799
Size: 42.37 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 616
View: 6050

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Alternative Toxicological Methods

by Harry Salem, Alternative Toxicological Methods Books available in PDF, EPUB, Mobi Format. Download Alternative Toxicological Methods books, Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist



Principles And Practice Of Skin Toxicology

Principles and Practice of Skin Toxicology PDF
Author: Robert Chilcott
Publisher: John Wiley & Sons
Release: 2008-07-31
ISBN: 0470773081
Size: 78.63 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 392
View: 4965

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Principles And Practice Of Skin Toxicology

by Robert Chilcott, Principles And Practice Of Skin Toxicology Books available in PDF, EPUB, Mobi Format. Download Principles And Practice Of Skin Toxicology books, Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.



Oecd Series On Testing And Assessment Guidance Document On Considerations For Waiving Or Bridging Of Mammalian Acute Toxicity Tests

OECD Series on Testing and Assessment Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests PDF
Author: OECD
Publisher: OECD Publishing
Release: 2017-04-13
ISBN: 9264274758
Size: 67.62 MB
Format: PDF, ePub, Mobi
Category :
Languages : en
Pages : 19
View: 2545

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Oecd Series On Testing And Assessment Guidance Document On Considerations For Waiving Or Bridging Of Mammalian Acute Toxicity Tests

by OECD, Oecd Series On Testing And Assessment Guidance Document On Considerations For Waiving Or Bridging Of Mammalian Acute Toxicity Tests Books available in PDF, EPUB, Mobi Format. Download Oecd Series On Testing And Assessment Guidance Document On Considerations For Waiving Or Bridging Of Mammalian Acute Toxicity Tests books, Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as ...



Alternatives To Animal Testing

Alternatives to Animal Testing PDF
Author: Hajime Kojima
Publisher: Springer
Release: 2019-01-28
ISBN: 9811324476
Size: 22.12 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 130
View: 7447

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Alternatives To Animal Testing

by Hajime Kojima, Alternatives To Animal Testing Books available in PDF, EPUB, Mobi Format. Download Alternatives To Animal Testing books, This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.



Advances In Animal Alternatives For Safety And Efficacy Testing

Advances In Animal Alternatives For Safety And Efficacy Testing PDF
Author: Harry Salem
Publisher: CRC Press
Release: 1997-11-12
ISBN: 1439805814
Size: 63.27 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 456
View: 7049

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Advances In Animal Alternatives For Safety And Efficacy Testing

by Harry Salem, Advances In Animal Alternatives For Safety And Efficacy Testing Books available in PDF, EPUB, Mobi Format. Download Advances In Animal Alternatives For Safety And Efficacy Testing books, Presents up-to-date concepts and approaches to the theory and practice of alternatives to animal testing and promotes technology transfer. The text addresses some of the ramifications of the National Institutes of Health Revitalization Act of 1993 which instructs the NIH to fund replacement, reduction and refinement alternatives. It also describes



Information Resources In Toxicology

Information Resources in Toxicology PDF
Author: Steve Gilbert
Publisher: Academic Press
Release: 2020-05-16
ISBN: 0128137258
Size: 35.12 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 1054
View: 3174

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Information Resources In Toxicology

by Steve Gilbert, Information Resources In Toxicology Books available in PDF, EPUB, Mobi Format. Download Information Resources In Toxicology books, This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources. Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles. Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals. Explores recent internet trends, web-based databases, and software tools in a section on the online environment. Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents. Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field.



Nanocosmetics

Nanocosmetics PDF
Author: Arun Nanda
Publisher: Micro and Nano Technologies
Release: 2020-05
ISBN: 0128222867
Size: 54.88 MB
Format: PDF, ePub, Docs
Category : Technology & Engineering
Languages : en
Pages : 500
View: 3927

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Nanocosmetics

by Arun Nanda, Nanocosmetics Books available in PDF, EPUB, Mobi Format. Download Nanocosmetics books, Nanotechnology is key to the design and manufacture of the new generation of cosmetics. Nanotechnology can enhance the performance and properties of cosmetics, including colour, transparency, solubility, texture, and durability. Sunscreen products, such as UV nano-filters, nano-TiO2 and nano-ZnO particles, can offer an advantage over their traditional counterparts due to their broad UV-protection and non-cutaneous side effects. For perfumes, nano‐droplets can be found in cosmetic products including Eau de Toilette and Eau de Parfum. Nanomaterials can also be used in cosmetics as transdermal drug delivery systems. By using smart nanocontainers, active compounds such as vitamins, antioxidants, nutrients, and anti-inflammatory, anti-infective agents, can be delivered effectively. These smart nanocontainers are typically related with the smart releasing property for their embedded active substances. These smart releases could be obtained by using the smart coatings as their outer nano-shells. These nano-shells could prevent the direct contact between these active agents and the adjacent local environments. Nanocosmetics: Fundamentals, Applications and Toxicity explores the formulation design concepts and emerging applications of nanocosmetics. The book also focuses on the mitigation or prevention of their potential nanotoxicity, potential global regulatory challenges, and the technical challenges of mass implementation. It is an important reference source for materials scientists and pharmaceutical scientists looking to further their understanding of how nanotechnology is being used for the new generation of cosmetics.



Reducing Refining And Replacing The Use Of Animals In Toxicity Testing

Reducing  Refining and Replacing the Use of Animals in Toxicity Testing PDF
Author: Dave Allen
Publisher: Royal Society of Chemistry
Release: 2013
ISBN: 1849736529
Size: 72.41 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 369
View: 793

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Reducing Refining And Replacing The Use Of Animals In Toxicity Testing

by Dave Allen, Reducing Refining And Replacing The Use Of Animals In Toxicity Testing Books available in PDF, EPUB, Mobi Format. Download Reducing Refining And Replacing The Use Of Animals In Toxicity Testing books, Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence." By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.



Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 498 In Vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity Test Method

OECD Guidelines for the Testing of Chemicals  Section 4 Test No  498  In vitro Phototoxicity   Reconstructed Human Epidermis Phototoxicity test method PDF
Author: OECD
Publisher: OECD Publishing
Release: 2021-06-17
ISBN: 9264353089
Size: 31.68 MB
Format: PDF
Category :
Languages : en
Pages : 28
View: 6179

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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 498 In Vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity Test Method

by OECD, Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 498 In Vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity Test Method Books available in PDF, EPUB, Mobi Format. Download Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 498 In Vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity Test Method books, Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.